Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants.
OBJECTIVE: The influence of post-ligation cardiac syndrome (PLCS), a complication of patent ductus arteriosus (PDA) ligations, on neonatal outcomes is unknown. The purpose of this study was to determine the risks of PLCS on severe pulmonary morbidity and severe retinopathy of prematurity (ROP).
STUDY DESIGN: Retrospective cohort study of infants who underwent a PDA ligation between 2006 and 2015. Data were collected on patients with and without PLCS. The primary outcome was the difference in severe bronchopulmonary dysplasia (BPD) between groups. Secondary outcomes included discharge with home oxygen and severe ROP.
RESULT: A total of 100 infants that underwent PDA ligation during the study period were included in the study; 31 (31%) neonates developed PLCS. In adjusted analysis, PLCS was associated with increased risk for severe BPD (RR 1.67, 95% CI: 1.15-2.42) and home oxygen therapy (RR: 1.47, 95% CI: 1.09-1.99) only. No association with severe ROP was seen (RR: 1.48; 95% CI: 0.87-2.52).
CONCLUSION: PLCS is associated with severe neonatal pulmonary morbidity, but not with severe ROP. Further investigation is warranted to validate these results.
Journal of perinatology : official journal of the California Perinatal Association
Cardiac Surgical Procedures; Ductus Arteriosus, Patent; Female; Humans; Infant, Newborn; Infant, Premature; Ligation; Logistic Models; Male; Morbidity; Perioperative Care; Postoperative Complications; Retrospective Studies; Syndrome
Cardiac Surgical Procedures; PatentDuctus Arteriosus; Ligation; Morbidity; Perioperative Care; Postoperative Complications
Ulrich TJB, Hansen TP, Reid KJ, Bingler MA, Olsen SL. Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants. J Perinatol. 2018;38(5):537-542. doi:10.1038/s41372-018-0056-4