The Role of a Single Dose of Vancomycin in Reducing Clinical Sepsis in Premature Infants Prior to Removal of Peripherally Inserted Central Catheter: A Retrospective Study.
OBJECTIVE: Peripherally inserted central catheter (PICC) line removal is associated with bloodstream infections and clinical sepsis. We aim to investigate the role of a single prophylactic dose of vancomycin in decreasing the incidence of central line associated bloodstream infection associated with PICC removal.
METHODS: A retrospective chart review of patients in the neonatal intensive care unit was conducted. Patients were divided into two study groups based on whether a single dose of vancomycin was administered (exposed) or not (nonexposed). The primary outcome measured was clinical sepsis with or without positive blood culture.
RESULTS: The incidence of clinical sepsis in the exposed group was 7.3% compared with 6.3% in the nonexposed group (
CONCLUSION: Our data do not support routine vancomycin prophylaxis prior to PICC line removal in premature infants to prevent sepsis associated with PICC removal. However, a large randomized controlled trial is further needed to delineate these results.
American journal of perinatology
Antibiotic Prophylaxis; Catheter-Related Infections; Catheterization, Central Venous; Catheters, Indwelling; Female; Gestational Age; Humans; Incidence; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Intensive Care Units, Neonatal; Male; Retrospective Studies; Sepsis; Texas; Vancomycin
Antibiotic Prophylaxis; Catheter-Related Infections; Central Venous Catheterization; Peripherally inserted central catheter; PICC; Indwelling Catheters; Sepsis; Vancomycin
Bhargava, V., George, L., Malloy, M., Fonseca, R. The Role of a Single Dose of Vancomycin in Reducing Clinical Sepsis in Premature Infants Prior to Removal of Peripherally Inserted Central Catheter: A Retrospective Study. American journal of perinatology 35, 990-993 (2018).