Document Type

Article

Publication Date

4-2020

Identifier

DOI: 10.1097/CCE.0000000000000093; PMCID: PMC7188439

Abstract

Pediatric oncology patients with sepsis are at higher risk of morbidity and mortality compared with pediatric patients without malignancy. Historically, patients with relapsed and/or refractory disease were not considered candidates for aggressive life support strategies including extracorporeal membrane oxygenation support.

Case Summary: We report a 4-year-old female with relapsed refractory pre-B cell acute lymphoblastic leukemia preparing for chimeric antigen receptor T cell therapy with tisagenlecleucel who was admitted with fever and neutropenia. She progressed to refractory septic shock secondary to

Conclusion: The ability to provide chimeric antigen receptor T-cell therapy at designated institutions can augment extracorporeal membrane oxygenation candidacy discussions in oncology patients with relapsed disease and may make extracorporeal membrane oxygenation candidacy for oncology patients with refractory sepsis more favorable.

Journal Title

Crit Care Explor

Volume

2

Issue

4

First Page

0093

Last Page

0093

Keywords

chimeric antigen receptor; extracorporeal membrane oxygenation; leukemia; pediatrics; sepsis.

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