Cardiovascular disease risk among children with focal segmental glomerulosclerosis: a report from the chronic kidney disease in children study.
DOI: 10.1007/s00467-019-04229-3; PMCID: PMC6594397 (available on 2020-08-01)
BACKGROUND: The aims were to compare the cardiovascular disease (CVD) risk among children with chronic kidney disease (CKD) secondary to focal segmental glomerulosclerosis (FSGS) with the CVD risk of children with CKD due to other diagnoses.
METHODS: Casual blood pressure (BP), ambulatory blood pressure monitoring (APBM), echocardiogram, lipids, carotid intima medial thickness (cIMT), and uric acid obtained from participants in the Chronic Kidney Disease in Children (CKiD) cohort were analyzed longitudinally. Seventy-nine children with FSGS (FSGS-CKD) were compared to 196 children with non-FSGS glomerular disease (GDO-CKD) and 616 children with non-glomerular disease (NG-CKD).
RESULTS: At baseline, FSGS-CKD (median 14 years) had ambulatory hypertension (24.6%), masked hypertension (46.2%), left ventricular hypertrophy (LVH) (26.3%), and dyslipidemia (60.0%). In adjusted models, FSGS-CKD had higher systolic BP z-score (0.52 vs 0.11 and 0.23, p = 0.002 and 0.02), triglycerides (133 vs 109 and 102 mg/dl, p = 0.007 and < 0.001), and non-high density lipoprotein (144 vs 132 and 119 mg/dl, p = 0.07 and < 0.001) at baseline when compared to GDO-CKD and NG-CKD, respectively. Left ventricular mass index (LVMI) (36.0 vs 31.7 g/m
CONCLUSIONS: Children with CKD due to FSGS had a relatively high prevalence of CVD risk factors. FSGS was associated with greater CVD risk when compared to other CKD diagnoses.
Pediatric nephrology (Berlin, Germany)
Adolescent; Blood Pressure Monitoring, Ambulatory; Cardiovascular Diseases; Carotid Intima-Media Thickness; Child; Child, Preschool; Disease Progression; Echocardiography; Female; Glomerulosclerosis, Focal Segmental; Humans; Infant; Longitudinal Studies; Male; Prevalence; Prospective Studies; Renal Insufficiency, Chronic; Risk Factors; Time Factors; Uric Acid
Carotid intima medial thickness; Dyslipidemia; Glomerular disease; Hypertension; Left ventricular hypertrophy; Pediatrics.
Sethna, C. B., Ng, D. K., Jiang, S., Saland, J., Warady, B. A., Furth, S., Meyers, K. E. Cardiovascular disease risk among children with focal segmental glomerulosclerosis: a report from the chronic kidney disease in children study. Pediatric nephrology (Berlin, Germany) 34, 1403-1412 (2019).