Relationships between chronotype, social jetlag, sleep, obesity and blood pressure in healthy young adults.
Sleep disturbances, chronotype and social jetlag (SJL) have been associated with increased risks for major chronic diseases that take decades to develop, such as obesity, metabolic syndrome and cardiovascular disease. Potential relationships between poor sleep, chronotype and SJL as they relate to metabolic risk factors for chronic disease have not been extensively investigated. This prospective study examined chronotype, SJL and poor sleep in relation to both obesity and elevated blood pressure among healthy young adults. SJL and objective sleep measures (total sleep time, sleep onset latency, wake after sleep onset and sleep efficiency) were derived from personal rest/activity monitoring (armband actigraphy) among 390 healthy adults 21-35 years old. Participants wore the device for 6-10 days at 6-month intervals over a 2-year period (n = 1431 repeated observations). Chronotypes were categorized into morning, intermediate and evening groups using repeated measures latent class analysis. Means of SJL and sleep measures among latent chronotype groups were compared using partial F-tests in generalized linear mixed models. Generalized linear mixed models also were used to generate odds ratios (ORs) with 95% confidence intervals (CIs) examining the relationship between repeated measures of chronotype, SJL, sleep and concurrent anthropometric outcome measures (body mass index, percentage of body fat, waist-to-hip ratio, waist-to-height ratio), systolic blood pressure and diastolic blood pressure. Sleep latency ≥12 min was associated with increased odds of a high waist-to-height ratio (OR = 1.37; CI: 1.03-1.84). Neither chronotype nor SJL was independently associated with anthropometric outcomes or with blood pressure. Relationships between poor sleep and anthropometric outcomes or blood pressure varied by chronotype. Morning types with total sleep time <6 >h, sleep efficiency
Actigraphy; Adult; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Body Weight; Circadian Rhythm; Female; Humans; Jet Lag Syndrome; Male; Sleep; Social Behavior; Young Adult
Actigraphy; body mass index; chronotype; repeated measures latent class analysis; sleep efficiency; social jetlag
McMahon, D. M., Burch, J. B., Youngstedt, S. D., Wirth, M. D., Hardin, J. W., Hurley, T. G., Blair, S. N., Hand, G. A., Shook, R. P., Drenowatz, C., Burgess, S., Hebert, J. R. Relationships between chronotype, social jetlag, sleep, obesity and blood pressure in healthy young adults. Chronobiology international 36, 493-509 (2019).