Title

First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis.

Document Type

Article

Publication Date

1-2015

Identifier

DOI: 10.1097/INF.0000000000000497

Abstract

Neonatal enteroviral sepsis is a potentially fatal condition. Perinatally acquired infection and severe coagulopathy can be associated with a poor clinical outcome, and antiviral therapy is currently unavailable. Pocapavir (V-073) is an investigational drug candidate being developed for poliovirus indications, but also has variable antiviral activity against nonpolio enteroviruses. We describe the first use of pocapavir in treating a case of severe neonatal enteroviral sepsis due to Coxsackievirus B3.

Journal Title

The Pediatric infectious disease journal

Volume

34

Issue

1

First Page

52

Last Page

54

MeSH Keywords

Antiviral Agents; Enterovirus B, Human; Enterovirus Infections; Female; Humans; Infant, Newborn; Poliovirus; Sepsis; Treatment Outcome

Keywords

Antiviral Agents; Enterovirus B, Human; Enterovirus Infections; Female; Humans; Infant, Newborn; Poliovirus; Sepsis; Treatment Outcome

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