General considerations for pediatric oral drug formulation
© American Association of Pharmaceutical Scientists 2014. In pediatrics, the absorption of a perorally administered drug depends on the ability of the formulation to overcome the chemical, physical, mechanical, and biological barriers of the developing gastrointestinal tract. The differences between the pediatric and adult digestive systems are subtle, but physiologically important, and encompass organs from mouth to anus. Although the exact age of GI function maturation remains to be defi ned, clinically relevant developmental changes that infl uence drug absorption occur primarily during early childhood. This chapter reviews the developmental changes in gastrointestinal physiology that occur throughout childhood and discusses their relevance to formulation development and drug delivery.
AAPS Advances in the Pharmaceutical Sciences Series
Autism Spectrum Disorder; Celiac Disease; Gastric Emptying; Young Infant; Apple Juice
Shakhnovich, V., Abdel-Rahman, S. M. General considerations for pediatric oral drug formulation AAPS Advances in the Pharmaceutical Sciences Series 11, 89-104 (2014).