General considerations for pediatric oral drug formulation

Creator(s)

Valentina Shakhnovich, Children's Mercy HospitalFollow
Susan M. Abdel-Rahman, Children's Mercy HospitalFollow

Document Type

Book Chapter

Publication Date

1-2014

Identifier

10.1007/978-1-4899-8011-3_7

Abstract

© American Association of Pharmaceutical Scientists 2014. In pediatrics, the absorption of a perorally administered drug depends on the ability of the formulation to overcome the chemical, physical, mechanical, and biological barriers of the developing gastrointestinal tract. The differences between the pediatric and adult digestive systems are subtle, but physiologically important, and encompass organs from mouth to anus. Although the exact age of GI function maturation remains to be defi ned, clinically relevant developmental changes that infl uence drug absorption occur primarily during early childhood. This chapter reviews the developmental changes in gastrointestinal physiology that occur throughout childhood and discusses their relevance to formulation development and drug delivery.

Journal Title

AAPS Advances in the Pharmaceutical Sciences Series

Volume

11

First Page

89

Last Page

104

Keywords

Autism Spectrum Disorder; Celiac Disease; Gastric Emptying; Young Infant; Apple Juice

Recommended Citation

Shakhnovich, V., Abdel-Rahman, S. M. General considerations for pediatric oral drug formulation AAPS Advances in the Pharmaceutical Sciences Series 11, 89-104 (2014).