A Moving Target-Vancomycin Therapeutic Monitoring

Creator(s)

Alaina N. Burns, Children's Mercy HospitalFollow
Jennifer Goldman, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

9-17-2020

Identifier

DOI: 10.1093/jpids/piaa078

Abstract

Therapeutic drug monitoring (TDM) has been a common practice to optimize efficacy and safety of vancomycin. While vancomycin trough-only TDM has widely been integrated into pediatric clinical practice since 2009, recently updated vancomycin TDM guidelines published in March 2020 recommend area under the curve (AUC) based TDM for vancomycin instead of trough-only TDM. In this review, we discuss the rationale behind the change in TDM recommendations, describe two approaches for calculating vancomycin AUC in clinical practice, and address considerations for integrating vancomycin AUC TDM into pediatric clinical practice. Our primary goal is to provide pediatric clinicians with a resource for implementing vancomycin AUC monitoring into clinical care.

Journal Title

Journal of the Pediatric Infectious Diseases Society

Volume

9

Issue

4

First Page

474

Last Page

478

Keywords

therapeutic drug monitoring; vancomycin

Recommended Citation

Burns AN, Goldman JL. A Moving Target-Vancomycin Therapeutic Monitoring. J Pediatric Infect Dis Soc. 2020;9(4):474-478. doi:10.1093/jpids/piaa078