Title

PharmVar GeneFocus: CYP2D6.

Document Type

Article

Publication Date

1-2020

Identifier

DOI: 10.1002/cpt.1643

Abstract

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Journal Title

Clinical pharmacology and therapeutics

Volume

107

Issue

1

First Page

154

Last Page

170

MeSH Keywords

Cytochrome P-450 CYP2D6; Databases, Genetic; Genetic Variation; Humans; Knowledge Bases; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

Keywords

Cytochrome P-450 CYP2D6; Databases, Genetic; Genetic Variation; Humans; Knowledge Bases; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic

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