Document Type

Article

Publication Date

11-2019

Identifier

DOI: 10.1111/cts.12668; PMCID: PMC6853152

Abstract

RNA interference via small interfering RNA (siRNA) offers opportunities to precisely target genes that contribute to gastrointestinal (GI) pathologies, such as inflammatory bowel disease, celiac, and esophageal scarring. Delivering the siRNA to the GI tract proves challenging as the harsh environment of the intestines degrades the siRNA before it can reach its target or blocks its entry into its site of action in the cytoplasm. Additionally, the GI tract is large and disease is often localized to a specific site. This review discusses polymer and lipid-based delivery systems for protection and targeting of siRNA therapies to the GI tract to treat local disease.

Journal Title

Clin Transl Sci

Volume

12

Issue

6

First Page

573

Last Page

585

MeSH Keywords

Administration, Oral; Animals; Cell Line; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Gastrointestinal Diseases; Gene Transfer Techniques; Humans; Lipids; Mice; Polymers; RNA, Small Interfering; RNAi Therapeutics

Keywords

Administration, Oral; Animals; Cell Line; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Gastrointestinal Diseases; Gene Transfer Techniques; Humans; Lipids; Mice; Polymers; RNA, Small Interfering; RNAi Therapeutics

Comments

Grant support

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Publisher's Online Access: https://doi.org/10.1111/cts.12668

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