Therapeutic Hypothermia in the Pediatric ICU

Document Type

Book Chapter

Publication Date



DOI 10.1007/978-3-319-96499-7_20; Print ISBN: 978-3-319-96498-0; Online ISBN: 978-3-319-96499-7


Therapeutic hypothermia (TH) is a complex therapy that has been shown to be robustly neuroprotective in experimental models of various neurologic conditions but has thus far been incompletely translated into patient care. Fever exacerbates neurologic injury and can contribute to worse patient outcomes. Patient temperature following neurologic insults has therefore become a vital sign to be continuously monitored and regulated. Targeted temperature management (TTM) encompasses both TH and the active prevention of fever (controlled normothermia). In this article, key literature is reviewed with a focus on traumatic brain injury (TBI) and hypoxic-ischemic brain injury, common situations associated with high morbidity and mortality in which clinicians are charged with the difficult task of making management decisions when the evidence is less than clear.

Journal Title

Pediatric Critical Care

First Page


Last Page



Cardia arrest; Hypothermia; Neurological outcome; Targeted temperature management; Monitoring; Traumatic brain injury

Library Record