The Effect on Somatic Growth of Surgical and Catheter Treatment of Secundum Atrial Septal Defects.
Historical studies suggest an association between atrial septal defect (ASD) and impaired growth with inconsistent improvement following closure. Limited data exist regarding the impact on growth in the era of transcatheter therapy. To evaluate the effect of closure on growth, we conducted a retrospective review of patients undergoing surgical or transcatheter closure during two time periods. Four hundred patients with isolated secundum ASD were divided into three cohorts: early surgical, contemporary surgical, and transcatheter. Data collected included demographics; height, weight, and body mass index (BMI) percentiles; catheterization hemodynamics; and co-morbidities. For all cohorts, there was no significant change in height or weight percentiles during two years after ASD closure. Age at repair was later for contemporary surgical and transcatheter cohorts (p < 0.0001). In the transcatheter cohort, mean Qp:Qs was 1.65 ± 0.54, but there was no correlation between greater Qp:Qs and decreased somatic growth. Subgroup analysis for patients with any initial growth percentile
Adolescent; Anthropometry; Cardiac Catheterization; Child; Child Development; Child, Preschool; Cohort Studies; Female; Growth Disorders; Heart Septal Defects, Atrial; Hemodynamics; Humans; Infant; Male; Retrospective Studies; Septal Occluder Device; Treatment Outcome
Atrial septal defect; Children; Congenital heart disease; Growth; Intervention
Chlebowski, M. M., Dai, H., Kaine, S. The Effect on Somatic Growth of Surgical and Catheter Treatment of Secundum Atrial Septal Defects. Pediatric cardiology 38, 1410-1414 (2017).