Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population
Aim: This study investigated major allelic variants of CYP2D6, CYP3A4 and CYP3A5 in Egyptians, an Arabic population for which there is little information regarding these important pharmacogenes.
Patients & methods: CYP2D6*2, *4, *5, *10, *41 and gene copy number variation, as well as CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 145 healthy study participants.
Results: The CYP2D6 alleles identified suggest that the prevalence of poor metabolizers is low as none were found among the 145 subjects investigated. The frequency for CYP3A5 nonexpressers was 74.5% and the CYP3A4*22 allele frequency was low at 2.0%.
Conclusion: These preliminary findings indicate that pharmacogene variation in Egyptians is different from those of other Middle Eastern/Arabic populations and warrants further investigation.
CYP2D6; CYP3A4; CYP3A5; genotype; phenotype Egyptian population
Mutawi, T. M., Zedan, M. M., Yahya, R. S., Zakria, M. M., El-Sawi, M. R., Gaedigk, A. Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population Pharmacogenomics 22, 323-334 (2021).