Document Type
Article
Publication Date
1-1-2016
Identifier
PMCID: PMC5685293 DOI: 10.1038/npjgenmed.2015.7
Abstract
An important component of precision medicine-the use of whole-genome sequencing (WGS) to guide lifelong healthcare-is electronic decision support to inform drug choice and dosing. To achieve this, automated identification of genetic variation in genes involved in drug absorption, distribution, metabolism, excretion and response (ADMER) is required.
Journal Title
NPJ Genom Med
Volume
1
First Page
15007
Last Page
15007
MeSH Keywords
Cytochrome P-450 CYP2D6; Phenotype; Whole Genome Sequencing; Precision Medicine
Keywords
Phenotype; Whole Genome Sequencing
Recommended Citation
Twist, G. P., Gaedigk, A., Miller, N. A., Farrow, E. G., Willig, L. K., Dinwiddie, D. L., Petrikin, J. E., Soden, S. E., Herd, S., Gibson, M., Cakici, J. A., Riffel, A. K., Leeder, J., Dinakarpandian, D., Kingsmore, S. F. Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, NPJ Genom Med 1, 15007-15007 (2016).
Included in
Health Information Technology Commons, Medical Genetics Commons, Medical Pharmacology Commons
Comments
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