Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS).
Drug screening is an essential component of clinical toxicology laboratory service. Some laboratories use only automated chemistry analyzers for limited screening of drugs of abuse and few other drugs. Other laboratories use a combination of various techniques such as immunoassays, colorimetric tests, and mass spectrometry to provide more detailed comprehensive drug screening. Mass spectrometry, gas or liquid, can screen for hundreds of drugs and is often considered the gold standard for comprehensive drug screening. We describe an efficient and rapid gas chromatography/mass spectrometry (GC/MS) method for comprehensive drug screening in urine which utilizes a liquid-liquid extraction, sample concentration, and analysis by GC/MS.
Methods in molecular biology (Clifton, N.J.)
Gas Chromatography-Mass Spectrometry; Humans; Liquid-Liquid Extraction; Substance Abuse Detection; Time Factors; Urinalysis
Comprehensive drug screening; Drug analysis; Drug screening; Gas Chromatography/Mass Spectrometry; GC/MS; Toxicology
Ramoo B, Funke M, Frazee C, Garg U. Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS). Methods Mol Biol. 2016;1383:125-131. doi:10.1007/978-1-4939-3252-8_15