PMCID: PMC4854431 DOI: 10.1016/j.jpeds.2015.09.040
OBJECTIVE: To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL).
STUDY DESIGN: Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy.
RESULTS: A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P = .053), lower achievement (95 vs 77.5; P < .05), and lower HRQoL by parent and child reports (effect estimates, -15.48; 95% CI, -28.71 to -2.24 and -18.39; 95% CI, -27.81 to -8.96, respectively). CDI score was not related to change in glomerular filtration rate.
CONCLUSION: Children with depression had lower psychoeducational skills and worse HRQoL. Identifying and treating depression should be evaluated as a means of improving the academic performance and HRQoL of children with chronic kidney disease.
The Journal of pediatrics
Adolescent; Child; Cohort Studies; Depression; Educational Status; Female; Glomerular Filtration Rate; Humans; Male; Prevalence; Quality of Life; Renal Insufficiency, Chronic; Severity of Illness Index
Kidney Disease; Renal Disease; GFR; Depression; Children; Teenagers; Chronic Illness
Kogon, Amy J.; Matheson, Matthew B.; Flynn, Joseph T.; Gerson, Arlene C.; Warady, Bradley A.; Furth, Susan L.; Hooper, Stephen R.; and Chronic Kidney Disease in Children (CKID) Study Group, "Depressive Symptoms in Children with Chronic Kidney Disease." (2016). Manuscripts, Articles, Book Chapters and Other Papers. 368.