Peripheral quantitative computed tomography (pQCT) bone measurements in children with cystic fibrosis.
Document Type
Article
Publication Date
1-1-2016
Identifier
DOI: 10.1002/ppul.23323
Abstract
BACKGROUND: Individuals with cystic fibrosis (CF) have low bone density and increased fracture risk.
METHODS: Cross-sectional study investigating whole body bone mineral content (WBBMC), bone geometry and strength in 12 children with CF compared to 23 age- and sex-matched controls with and without adjusting for age, height, and body composition.
RESULTS: CF group had lower WBBMC than controls (P = 0.007) with larger differences at older ages (age-by-group, P = 0.08). CF group had decreased height (P = 0.006), a trend of lower lean mass per height (P = 0.08), and no difference in relationship between WBBMC and lean mass compared to controls (P = 0.65). Periosteal and endosteal circumferences were smaller in CF (each, P = 0.02). Positive relationships of cortical area and bone strength with age were attenuated with CF (group-by-age; each, P < 0.01).
CONCLUSION: Children with CF have similar WBBMC relative to lean mass as controls. Cortical bone area and bone strength were less in CF group compared to controls, with greater differences in older children.
Journal Title
Pediatric pulmonology
Volume
51
Issue
1
First Page
28
Last Page
33
MeSH Keywords
Absorptiometry, Photon; Adolescent; Body Composition; Bone Density; Bone and Bones; Child; Cross-Sectional Studies; Cystic Fibrosis; Female; Humans; Male
Keywords
DXA; bone size; bone strength; cystic fibrosis; whole body bone mineral content
Recommended Citation
Bai W, Binkley TL, Wallace JW, Carver TW Jr, Specker BL. Peripheral quantitative computed tomography (pQCT) bone measurements in children with cystic fibrosis. Pediatr Pulmonol. 2016;51(1):28-33. doi:10.1002/ppul.23323
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