Title

Hungry Bone Syndrome Secondary to Subtotal Thyroidectomy in A Patient With Thyrotoxicosis.

Document Type

Article

Publication Date

9-2021

Identifier

DOI: 10.1016/j.amjms.2021.02.006

Abstract

Patients with thyrotoxicosis are prone to transient hypocalcemia after thyroidectomy, which may be due in part to surgical damage to the parathyroid glands. Hungry bone syndrome (HBS) can also cause hypocalcemia after thyroidectomy. HBS is due to increased osteoblast-mediated bone formation activity and normal or decreased bone resorption activity. As HBS is uncommon in patients after thyroidectomy, we herein present a case of hypocalcemia secondary to HBS after subtotal thyroidectomy for thyrotoxicosis in a 25-year-old woman with a two-month history of tingling extremities and carpopedal spasms after subtotal thyroidectomy for thyrotoxicosis. Diagnostic tests showed hypocalcemia and hyperphosphatemia with elevated parathyroid hormone levels and moderately decreased serum 25-hydroxyvitamin D levels. In addition to thyroid hormone replacement therapy, she was given calcitriol and Caltrate D (600 mg calcium plus 125 IU cholecalciferol). After two months of treatment, she no longer had spasms and her paresthesia improved. Meanwhile, serum electrolytes and parathyroid hormone levels had almost returned to the normal ranges. This is a rare case of HBS presented as a complication of subtotal thyroidectomy in a patient with thyrotoxicosis.

Journal Title

The American journal of the medical sciences

Volume

362

Issue

3

First Page

314

Last Page

320

MeSH Keywords

Adult; Calcitriol; Female; Humans; Hypocalcemia; Hypothyroidism; Postoperative Complications; Syndrome; Thyroidectomy; Thyrotoxicosis; Thyroxine

Keywords

Hungry bone syndrome; Hypocalcemia; Thyroidectomy; Thyrotoxicosis

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