A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants.
OBJECTIVE: The objective of the study was to compare the effect of two different dexamethasone regimens on respiratory outcomes of ventilator-dependent preterm infants.
STUDY DESIGN: Retrospective study of ventilated preterm infantstherapy.
RESULTS: Fifty-nine infants were identified; 32 (54%) received 7 days of dexamethasone and 27 (46%) received 10 days of dexamethasone. Both groups had comparable baseline demographics and clinical characteristics. Mean time to successful extubation was similar between the two groups (5.1±2.7 days in 7-day group and 6.0±3.7 days in 10-day group, P=0.42). Successful extubation by end of treatment (56% versus 67%, P=0.44) and need for repeat steroid therapy (47% versus 33%, P=0.43) were also similar.
CONCLUSION: 7-day and 10-day course of dexamethasone have comparable efficacy in facilitating extubation of ventilator-dependent preterm infants.
Journal of perinatology : official journal of the California Perinatal Association
Bronchopulmonary Dysplasia; Dexamethasone; Drug Administration Schedule; Female; Glucocorticoids; Humans; Infant, Newborn; Infant, Premature; Kaplan-Meier Estimate; Male; Missouri; Respiration, Artificial; Respiratory Distress Syndrome, Newborn; Retrospective Studies; Treatment Outcome
Bronchopulmonary Dysplasia; BPD; Preemies; Respiratory Distress Syndrome
Cuna, A., Govindarajan, S., Oschman, A., Dai, H., Brophy, K., Norberg, M., Truog, W. E. A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants. Journal of perinatology : official journal of the California Perinatal Association 37, 301-305 (2017).