Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update.

Document Type

Article

Publication Date

11-2022

Identifier

DOI: 10.1002/cpt.2526

Abstract

CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition and increased risk for major adverse cardiovascular and cerebrovascular events. This guideline is an update to the 2013 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of clopidogrel based on CYP2C19 genotype and includes expanded indications for CYP2C19 genotype-guided antiplatelet therapy, increased strength of recommendation for CYP2C19 intermediate metabolizers, updated CYP2C19 genotype to phenotype translation, and evidence from an expanded literature review (updates at www.cpicpgx.org).

Journal Title

Clinical pharmacology and therapeutics

Volume

112

Issue

5

First Page

959

Last Page

967

MeSH Keywords

Clopidogrel; Cytochrome P-450 CYP2C19; Platelet Aggregation Inhibitors; Pharmacogenetics; Ticlopidine; Prodrugs; Genotype

Keywords

Clopidogrel; Cytochrome P-450 CYP2C19; Platelet Aggregation Inhibitors; Pharmacogenetics; Ticlopidine; Prodrugs; Genotype

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