Pediatric leukodystrophies are rare neurodegenerative diseases involving multiple systems. Each form has unique neurologic features but are characterized by encephalopathy with accompanying impairments evidenced in reflexes, muscle tone and movement control. Weakness of expiratory, inspiratory, and upper airway muscles may lead to impaired airway secretion clearance resulting in recurrent respiratory infections, dysphagia, sleep-disordered breathing, restrictive lung disease, and ultimately chronic respiratory insufficiency.
Current problems in pediatric and adolescent health care
Humans; Child; Sleep Apnea Syndromes
Sleep Apnea Syndromes
Perez G, Young L, Kravitz R, et al. Pulmonological issues. Curr Probl Pediatr Adolesc Health Care. 2022;52(12):101313. doi:10.1016/j.cppeds.2022.101313