Recurrence Rates for Pediatric Benign Ovarian Neoplasms.

Creator(s)

Maria E. Knaus
Amanda J. Onwuka
Naila M. Abouelseoud
Katherine C. Bergus
Lesley L. Breech
Katherine S. Brito
Charlene Dekonenko, Children's Mercy Kansas CityFollow
S Paige Hertweck
Helena Y. Hong
Seema Menon
Diane F. Merritt
Allegra G. Schikler
Nikki Senapati
Yolanda R. Smith
Julie L. Strickland, Children's Mercy Kansas City
Amber I. Truehart
Peter C. Minneci
Geri D. Hewitt

Document Type

Article

Publication Date

4-2023

Identifier

DOI: 10.1016/j.jpag.2022.11.006

Abstract

STUDY OBJECTIVE: To examine the recurrence rates of pediatric benign ovarian neoplasms METHODS: A retrospective review of females up to 21 years of age who underwent surgery for a benign ovarian neoplasm at 8 pediatric hospitals from January 2010 through December 2016 was conducted. Data include primary operation details, follow-up imaging, and reoperation details.

RESULTS: Four hundred and twenty-six females were included in our cohort, with a median age of 15 years at the time of the primary operation. Of the patients, 69% had a mature teratoma, 18% had a serous cystadenoma, and 8% had a mucinous cystadenoma. Two-thirds of patients underwent ovarian-sparing surgery. There were 11 pathologically confirmed recurrences (2.6%) at a median follow-up of 12.8 months. The pathologically confirmed recurrence was 10.5 per 100 person-months at 12 months (SE = 5.7) for mucinous cystadenomas and 0.4 months (SE = 0.4) for mature teratomas (P = .001). For half of the patients, the pathologically confirmed recurrences occurred by 12.8 months, and for 75%, they occurred by 23.3 months. There were no differences in reoperation or recurrence on the basis of initial procedure (ovary-sparing surgery vs oophorectomy).

CONCLUSION: We measured the pathologically confirmed recurrence rate for pediatric benign ovarian neoplasms in a large cohort. Oophorectomy was not protective against recurrence. Mucinous cystadenomas were at a greater risk of pathologically confirmed recurrence.

Journal Title

Journal of pediatric and adolescent gynecology

Volume

36

Issue

2

First Page

160

Last Page

166

MeSH Keywords

Child; Humans; Female; Adolescent; Cystadenoma, Mucinous; Ovarian Neoplasms; Teratoma; Dermoid Cyst; Retrospective Studies

Keywords

Dermoid cyst; Mature cystic teratoma; Mature teratoma; Mucinous cystadenoma; Serous cystadenoma

Recommended Citation

Knaus ME, Onwuka AJ, Abouelseoud NM, et al. Recurrence Rates for Pediatric Benign Ovarian Neoplasms. J Pediatr Adolesc Gynecol. 2023;36(2):160-166. doi:10.1016/j.jpag.2022.11.006