Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1.
OBJECTIVES: Classic treatment for syndrome of inappropriate antidiuretic hormone (SIADH) is fluid restriction. However, this is not ideal for infants who need large fluid volumes to ensure adequate caloric intake for growth. The use of urea has not been thoroughly studied in children.
CASE PRESENTATION: This infant had SIADH complicated by poor growth, solitary central incisor, and NF1. Following failed attempts to correct hyponatremia with fluid restriction and other therapeutics, urea normalized sodium levels and allowed liberalization of formula volumes, which resulted in improved weight gain.
CONCLUSIONS: Urea is a safe, cost-effective, long-term treatment for SIADH in infants who are unable to fluid restrict due to caloric goals.
Journal of pediatric endocrinology & metabolism : JPEM
Child; Infant; Humans; Hyponatremia; Inappropriate ADH Syndrome; Urea; Incisor; Neurofibromatosis 1; Vasopressins
SIADH; solitary central incisor; urea
Cui J, Halpin K, Paprocki E. Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1. J Pediatr Endocrinol Metab. 2022;36(4):430-434. Published 2022 Nov 24. doi:10.1515/jpem-2022-0294