Optimizing fluid resuscitation in hypertrophic pyloric stenosis.

Document Type


Publication Date



DOI: 10.1016/j.jpedsurg.2016.01.013


BACKGROUND: Hypertrophic pyloric stenosis (HPS) is the most common diagnosis requiring surgery in infants. Electrolytes are used as a marker of resuscitation for these patients prior to general anesthesia induction. Often multiple fluid boluses and electrolyte panels are needed, delaying operative intervention. We have attempted to predict the amount of IV fluid boluses needed for electrolyte correction based on initial values.

METHODS: A single center retrospective review of all patients diagnosed with HPS from 2008 through 2014 was performed. Abnormal electrolytes were defined as chloride <100mmol/L, bicarbonate ≥30mmol/L or potassium >5.2 or <3.1mmol/L. Patients with abnormal electrolytes were resuscitated with 20ml/kg saline boluses and continuous fluids at 1.5 times maintenance rate.

RESULTS: During the study period 542 patients were identified with HPS. Of the 505 who were analyzed 202 patients had electrolyte abnormalities requiring IV fluid resuscitation above maintenance, and 303 patients had normal electrolytes at time of diagnosis. Weight on presentation was significantly lower in the patients with abnormal electrolytes (3.8 vs 4.1kg, p

CONCLUSION: Children with electrolyte abnormalities at time of diagnosis of HPS have a longer length of stay; require more fluid resuscitation and more lab draws. This study reveals high sensitivity and specificity of presenting chloride in determining the need for multiple boluses. We recommend the administration of two 20ml/kg saline boluses separated by an hour prior to rechecking labs in patients with initial Cl(-) value ≤97mmol/L. If the presenting Cl(-)/kg of saline separated by an hour are recommended. If implemented these modifications have potential to save time by not delaying care for extraneous lab results and money in the form of fewer lab draws.

Journal Title

Journal of pediatric surgery





First Page


Last Page


MeSH Keywords

Bicarbonates; Chlorides; Electrolytes; Female; Fluid Therapy; Humans; Infant; Male; Potassium; Pyloric Stenosis, Hypertrophic; ROC Curve; Resuscitation; Retrospective Studies; Sensitivity and Specificity; Sodium Chloride


Bicarbonate; Chloride; Electrolyte abnormalities; Fluid resuscitation; Hypertrophic pyloric stenosis; Pyloromyotomy

Library Record