Pulmonary hypertension predicts mortality in infants with omphalocele.
OBJECTIVE: The objective of this study was to identify predictors of mortality in infants with omphalocele.
METHODS: Medical records of infants with omphalocele born between January 1992 and June 2012, with follow-up toDecember 2012, were retrospectively reviewed. Survivors and non-survivors were compared. Evidence for pulmonary hypertension was sought between the second and seventh day after birth. All included infants had increased right ventricular pressures (RVP >40 mmhg) on echocardiogram on the second day of life with increased oxygen requirements, therefore, the finding of increased pressure was not considered a result of the transitional circulation. Logistic regression was used to evaluate the importance and independence of various factors.
RESULTS: Of 51 infants whose records were reviewed, 13 died (25%) and 38 survived (75%). The median time to death was 34 days (range: 4 -408 days). The median follow-up time for those who died was 1.5 years (range: 0.01-15 years) and for survivors was 2.6 years (range: 0.08-15 years). Logistic regression revealed that respiratory insufficiency at birth (OR: 14.8; 95% CI: 2.5-85.0) and pulmonary hypertension (OR: 6.4; 95% CI: 1.1-39.0) were independently associated with mortality.
CONCLUSION: Respiratory insufficiency after birth and pulmonary hypertension are independent predictors of mortality in infants with omphalocele.
J Neonatal Perinatal Med
Child, Preschool; Comorbidity; Female; Hernia, Umbilical; Humans; Hypertension, Pulmonary; Infant; Infant, Newborn; Male; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Survival Rate; Time Factors
Pulmonary hypertension; infant; omphalocele; respiratory insufficiency; ventilator
Baerg, J E.; Thorpe, D L.; Sharp, N E.; Ramlogan, S R.; Hutson, S M.; Goff, D A.; Hopper, A O.; and St Peter, Shawn D., "Pulmonary hypertension predicts mortality in infants with omphalocele." (2015). Manuscripts, Articles, Book Chapters and Other Papers. 869.