Title

The role of 2-octyl cyanoacrylate in prevention of penile adhesions after circumcision: A prospective, randomized trial.

Document Type

Article

Publication Date

12-1-2017

Identifier

DOI: 10.1016/j.jpedsurg.2017.08.052

Abstract

PURPOSE: Penile adhesions are the most common complication after circumcision, although strategies to decrease them are poorly studied. We conducted a prospective, randomized trial comparing the use of 2-octyl cyanoacrylate (glue) skin adhesive to hydrophobic ointment after circumcision.

METHODS: Patients0.05, 168 patients were calculated for each arm. Because of high attrition, we planned to include up to 500 patients. Presence/absence of adhesions was evaluated 2-4weeks postop. Parents subjectively scored happiness, comfort, distress, and concern on a Likert scale 1-5.

RESULTS: From 11/2012 through 7/2016, 409 patients were enrolled. Adhesion data were available on 243 patients. There was no difference between glue (16.8%) and those with antibiotic ointment (15.2%) (p=0.88) or in parental satisfaction across all areas measured. 165 patients were lost to follow-up, evenly distributed between the two groups (38% vs. 42%, p=0.49).

CONCLUSION: The placement of 2-octyl cyanoacrylate skin adhesive does not decrease the rate of postoperative penile adhesions after circumcision. Parent satisfaction outcomes are similar.

TYPE OF STUDY: Treatment study.

LEVEL OF EVIDENCE: Level II.

Journal Title

Journal of pediatric surgery

Volume

52

Issue

12

First Page

1886

Last Page

1890

MeSH Keywords

Anti-Bacterial Agents; Circumcision, Male; Cyanoacrylates; Humans; Infant; Infant, Newborn; Male; Prospective Studies; Sutures; Tissue Adhesions; Tissue Adhesives; Treatment Outcome

Keywords

2-Octyl cyanoacrylate; Circumcision; Penile adhesion

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