Title

Current issues and perspectives in hypoplasia of the left heart.

Document Type

Article

Publication Date

2-1-2005

Identifier

DOI: 10.1017/S1047951105000132

Abstract

Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.

Journal Title

Cardiology in the young

Volume

15

Issue

1

First Page

56

Last Page

72

MeSH Keywords

Animals; Aortic Valve; Aortic Valve Stenosis; Coronary Circulation; Disease Models, Animal; Echocardiography, Doppler; Fetus; Heart Septal Defects, Ventricular; Humans; Hypoplastic Left Heart Syndrome; Infant; Mitral Valve; Prenatal Diagnosis; Vascular Resistance

Keywords

HLHS

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