Current issues and perspectives in hypoplasia of the left heart.
Document Type
Article
Publication Date
2-1-2005
Identifier
DOI: 10.1017/S1047951105000132
Abstract
Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.
Journal Title
Cardiology in the young
Volume
15
Issue
1
First Page
56
Last Page
72
MeSH Keywords
Animals; Aortic Valve; Aortic Valve Stenosis; Coronary Circulation; Disease Models, Animal; Echocardiography, Doppler; Fetus; Heart Septal Defects, Ventricular; Humans; Hypoplastic Left Heart Syndrome; Infant; Mitral Valve; Prenatal Diagnosis; Vascular Resistance
Keywords
HLHS
Recommended Citation
Sedmera, D., Cook, A. C., Shirali, G. S., McQuinn, T. C. Current issues and perspectives in hypoplasia of the left heart. Cardiology in the young 15, 56-72 (2005).
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