Current issues and perspectives in hypoplasia of the left heart.
Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.
Cardiology in the young
Animals; Aortic Valve; Aortic Valve Stenosis; Coronary Circulation; Disease Models, Animal; Echocardiography, Doppler; Fetus; Heart Septal Defects, Ventricular; Humans; Hypoplastic Left Heart Syndrome; Infant; Mitral Valve; Prenatal Diagnosis; Vascular Resistance
Sedmera, D., Cook, A. C., Shirali, G. S., McQuinn, T. C. Current issues and perspectives in hypoplasia of the left heart. Cardiology in the young 15, 56-72 (2005).