Prevention of neonatal vitamin A deficiency is related to the adequacy of maternal vitamin A stores. In this study we investigated maternal and cord serum vitamin A and retinol-binding protein (RBP) values in an Indian population including, for the first time, clinically vitamin A-deficient mothers. Twenty-eight maternal-neonatal pairs were selected from maternal cohorts of high socioeconomic status without clinical evidence of vitamin A deficiency (group I) and low socioeconomic status with conjunctival xerosis and Bitot's spots (group II). Maternal education, caloric and vitamin A intakes, weight, height, hemoglobin, and birth weight were significantly lower in group II. Serum vitamin A levels were significantly higher in group I mothers and newborns as were RBP levels in group I mothers. However, a significant difference between groups I and II in cord blood RBP was not observed. Upon correlation of maternal vitamin A levels with cord blood vitamin A levels, a logarithmic relationship was revealed, suggesting saturable transplacental transport of vitamin A.
Journal of pediatric gastroenterology and nutrition
Adult; Female; Fetal Blood; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Retinol-Binding Proteins; Vitamin A; Vitamin A Deficiency
Shirali, G. S., Oelberg, D. G., Mehta, K. P. Maternal-neonatal serum vitamin A concentrations. Journal of pediatric gastroenterology and nutrition 9, 62-66 (1989).