Title

Diuretics in the treatment of hypertension.

Document Type

Article

Publication Date

12-1-2016

Identifier

DOI: 10.1007/s00467-016-3334-4

Abstract

Diuretics have long been used for the treatment of hypertension. Thiazide diuretics are the most commonly prescribed diuretics for hypertension, but other classes of diuretics may be useful in alternative circumstances. Although diuretics are no longer considered the preferred agent for treatment of hypertension in adults and children, they remain acceptable first-line options. Diuretics effectively decrease blood pressure in hypertensive patients, and in adults with hypertension reduce the risk of adverse cardiovascular outcomes. Because of varied pharmacokinetic and pharmacodynamic differences, chlorthalidone may be the preferred thiazide diuretic in the treatment of primary hypertension. Other types of diuretics (e.g., loop, potassium sparing) may be useful for the treatment of hypertension related to chronic kidney disease (CKD) and other varied conditions. Common side effects of thiazides are mostly dose-related and involve electrolyte and metabolic abnormalities.

Journal Title

Pediatric nephrology (Berlin, Germany)

Volume

31

Issue

12

First Page

2223

Last Page

2233

MeSH Keywords

Adolescent; Antihypertensive Agents; Child; Child, Preschool; Diuretics; Guidelines as Topic; Humans; Hypertension; Infant; Infant, Newborn; Thiazides

Keywords

Children; Chlorthalidone; Diuretics; Hydrochlorothiazide; Hypertension; Thiazide diuretic

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