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The goal of this research project is to identify and characterize potentially novel antineoplastic agents that could specifically degrade conformational mutP53 protein in cancer cells. We concluded that treatment of cancer cells with curcumin or PLINH compounds inhibit proliferation of cancer cells in a DNAJA1-misfolded mutp5-dependent manner. Delineation of the exact mechanism through which curcumin and PLINH exert their anti-cancer effects could pave the way for promising novel preventive and therapeutic modalities for cancer.
Tumor Suppressor Protein p53; Curcumin; Plumbagin; Isoniazid; Antineoplastic Agents
Medical Genetics | Neoplasms | Oncology | Translational Medical Research
When and Where Presented
Children's Mercy Kansas City Research Days, May 2019
Alalem, Mohamed A.A.; Farooki, Sana; and Iwakuma, Tomoo, "Mutant p53 Depletion by Natural Compounds" (2019). Presentations. 17.