Document Type
Article
Publication Date
1-1-2017
Identifier
PMCID: PMC5471592 DOI: 10.1155/2017/3074240
Abstract
Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation. Current treatment modality is surgical resection. We discuss a 12-year-old female who presented following resection of a pure ovarian immature teratoma (grade 3, FIGO stage IIIC). Following chemotherapy and resection of a pelvic/liver recurrence demonstrating mature teratoma, she underwent molecular genetics based chemotherapeutic treatment. No standardized management protocol has been established for the treatment of GTS. The effect of chemotherapeutic agents for decreasing the volume of and prevention of expansion is unknown. We review in detail the history, diagnostic algorithm, and previous reported pediatric cases as well as treatment options for pediatric patients with GTS.
Journal Title
Case Rep Surg
Volume
2017
First Page
3074240
Last Page
3074240
MeSH Keywords
Ovarian Neoplasms; Teratoma; Child
Keywords
Growing Teratoma Syndrome; Immature ovarian teratoma; Case report; Children
Recommended Citation
Rentea RM, Varghese A, Ahmed A, et al. Pediatric Ovarian Growing Teratoma Syndrome. Case Rep Surg. 2017;2017:3074240. doi:10.1155/2017/3074240
Included in
Neoplasms Commons, Oncology Commons, Pathology Commons, Pediatrics Commons, Surgery Commons
Comments
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher's Link: https://www.hindawi.com/journals/cris/2017/3074240/