Bisphosphonates use in children.

Creator(s)

Judith F. Sebestyen
Tarak Srivastava, Children's Mercy HospitalFollow
Uri S. Alon, Chilidren's Mercy HospitalFollow

Document Type

Article

Publication Date

11-1-2012

Identifier

DOI: 10.1177/0009922812452118

Abstract

Bisphosphonates are synthetic analogues of pyrophosphate that inhibit bone resorption by their action on osteoclasts. In recent years, bisphosphonates have been used in children for treatment of a growing number of disorders associated primarily with generalized or localized osteoporosis, genetic and acquired metabolic bone diseases, heterotopic calcifications in soft tissues, and for hypercalcemia. In this review, the authors address the role of and experience with bisphosphonate therapy in disorders of childhood.

Journal Title

Clinical pediatrics

Volume

51

Issue

11

First Page

1011

Last Page

1024

MeSH Keywords

Absorptiometry, Photon; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Child; Clinical Trials as Topic; Diphosphonates; Evidence-Based Medicine; Humans; Hypercalcemia; Osteoclasts; Osteoporosis; Treatment Outcome

Recommended Citation

Sebestyen, J. F., Srivastava, T., Alon, U. S. Bisphosphonates use in children. Clinical pediatrics 51, 1011-1024 (2012).