Bisphosphonates for pain management in children with benign cartilage tumors.
Document Type
Article
Publication Date
3-1-2012
Identifier
DOI: 10.1097/AJP.0b013e3182290fae
Abstract
OBJECTIVES: Cochrane meta-analyses have shown significant benefit in bone pain from bisphosphonate therapy in adults with bone diseases such as multiple myeloma, Paget disease, breast and prostate cancer. Our aim was to assess if bisphosphonate treatment could alleviate severe pain in children with Ollier disease and hereditary multiple exostoses that are refractory to standard analgesics.
METHODS: We report our clinical experience with bisphosphonate therapy in 2 children with cartilage tumors, one with Ollier disease, and the other with hereditary multiple exostoses.
RESULTS: We found bisphosphonate therapy to be helpful for pain relief and improving overall ability to carry out daily activities.
DISCUSSION: One can consider bisphosphonate therapy in children with Ollier disease and hereditary multiple exostoses who have debilitating pain that is refractory to standard analgesic treatment.
Journal Title
The Clinical journal of pain
Volume
28
Issue
3
First Page
268
Last Page
272
MeSH Keywords
Bone Density Conservation Agents; Bone Neoplasms; Cartilage; Child; Diphosphonates; Female; Humans; Male; Pain; Pain Measurement
Recommended Citation
Winston, M. J., Srivastava, T., Jarka, D. E., Alon, U. S. Bisphosphonates for pain management in children with benign cartilage tumors. The Clinical journal of pain 28, 268-272 (2012).
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