Bisphosphonates for pain management in children with benign cartilage tumors.
OBJECTIVES: Cochrane meta-analyses have shown significant benefit in bone pain from bisphosphonate therapy in adults with bone diseases such as multiple myeloma, Paget disease, breast and prostate cancer. Our aim was to assess if bisphosphonate treatment could alleviate severe pain in children with Ollier disease and hereditary multiple exostoses that are refractory to standard analgesics.
METHODS: We report our clinical experience with bisphosphonate therapy in 2 children with cartilage tumors, one with Ollier disease, and the other with hereditary multiple exostoses.
RESULTS: We found bisphosphonate therapy to be helpful for pain relief and improving overall ability to carry out daily activities.
DISCUSSION: One can consider bisphosphonate therapy in children with Ollier disease and hereditary multiple exostoses who have debilitating pain that is refractory to standard analgesic treatment.
The Clinical journal of pain
Bone Density Conservation Agents; Bone Neoplasms; Cartilage; Child; Diphosphonates; Female; Humans; Male; Pain; Pain Measurement
Winston, M. J., Srivastava, T., Jarka, D. E., Alon, U. S. Bisphosphonates for pain management in children with benign cartilage tumors. The Clinical journal of pain 28, 268-272 (2012).