Use of calcimimetics in children with normal kidney function.
Document Type
Article
Publication Date
3-1-2019
Identifier
DOI: 10.1007/s00467-018-3935-1
Abstract
The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. The current review briefly discusses the role of the CaSR and calcimimetics in calcium homeostasis, and then addresses the potential applications of calcimimetics in children with normal kidney function with disorders in which suppression of PTH is beneficial.
Journal Title
Pediatric nephrology (Berlin, Germany)
Volume
34
Issue
3
First Page
413
Last Page
422
MeSH Keywords
Parathyroid Hormone; Receptors, Calcium-Sensing; Child; Adolescent
Keywords
Calcimimetics; Calcium-sensing receptor; Hyperparathyroidism; Parathyroid hormone; Rickets
Recommended Citation
VanSickle JS, Srivastava T, Alon US. Use of calcimimetics in children with normal kidney function. Pediatr Nephrol. 2019;34(3):413-422. doi:10.1007/s00467-018-3935-1
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