Title

Use of calcimimetics in children with normal kidney function.

Document Type

Article

Publication Date

3-1-2019

Identifier

DOI: 10.1007/s00467-018-3935-1

Abstract

The calcium-sensing receptor (CaSR) plays an important role in the homeostasis of serum ionized calcium by regulating parathyroid hormone (PTH) secretion and tubular calcium handling. Calcimimetics, which act by allosteric modulation of the CaSR, mimic hypercalcemia resulting in suppression of PTH release and increase in calciuria. Mostly used in children to treat secondary hyperparathyroidism associated with advanced renal failure, we have shown that calcimimetics can also be successfully used in children with bone and mineral disorders in which elevated PTH plays a detrimental role in skeletal pathophysiology in the face of normal kidney function. The current review briefly discusses the role of the CaSR and calcimimetics in calcium homeostasis, and then addresses the potential applications of calcimimetics in children with normal kidney function with disorders in which suppression of PTH is beneficial.

Journal Title

Pediatric nephrology (Berlin, Germany)

Volume

34

Issue

3

First Page

413

Last Page

422

MeSH Keywords

Parathyroid Hormone; Receptors, Calcium-Sensing; Child; Adolescent

Keywords

Calcimimetics; Calcium-sensing receptor; Hyperparathyroidism; Parathyroid hormone; Rickets

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