Sustained beneficial effect of intravenous bisphosphonates after their discontinuation in children.
Document Type
Article
Publication Date
2-1-2007
Identifier
DOI: 10.1007/s00467-006-0306-0
Abstract
We studied if the beneficial effects of bisphosphonates are maintained after their discontinuation, and whether adverse effects may develop. Seventeen children in whom I.V. bisphosphonates were discontinued for at least 12 months were included. Fracture rate (FR), skeletal pain, bone mineral density of total body (TB) and spine L(2-4), skeletal radiographs, bone markers and kidney functions were compared between: (a) before treatment, (b) end of treatment, and (c) last follow-up. Mean treatment duration was 22+/-2 months (6-43) and follow-up 26+/-2 months (18-44). FR (mean +/- SD) decreased from 0.74+/-0.21/year before treatment to 0.35+/-0.11/year after treatment and 0.20+/-0.09/year at follow-up (p
Journal Title
Pediatric nephrology (Berlin, Germany)
Volume
22
Issue
2
First Page
282
Last Page
287
MeSH Keywords
Adolescent; Bone Density; Bone Diseases, Metabolic; Child; Child, Preschool; Diphosphonates; Female; Follow-Up Studies; Humans; Male; Osteogenesis; Osteoporosis; Retrospective Studies; Time
Recommended Citation
Waterhouse, K. M., Auron, A., Srivastava, T., Haney, C. J., Alon, U. S. Sustained beneficial effect of intravenous bisphosphonates after their discontinuation in children. Pediatric nephrology (Berlin, Germany) 22, 282-287 (2007).
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