Pediatric pharmacokinetics.

Creator(s)

Jonathan B. Wagner, Children's Mercy HospitalFollow
Susan M. Abdel-Rahman, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

6-1-2013

Identifier

DOI: 10.1542/pir.34-6-258

Abstract

OBJECTIVES: After reading this article, the reader should be able to 1. Realize that volume of distribution, elimination clearance, and elimination half-life are crucial parameters of pharmacokinetics that must be understood to determine clinical pharmacologic decisions.2. Know that drug disposition is a complicated process of absorption, distribution,metabolism, and excretion. 3. Understand that any abnormality in absorption, distribution, metabolism, and/or excretion can potentially affect the efficacy or toxicity of a drug. 4. Understand that the anatomical and physiologic changes during development must be considered in predicting age-dependent changes in drug disposition.

Journal Title

Pediatrics in review / American Academy of Pediatrics

Volume

34

Issue

6

First Page

258

Last Page

269

MeSH Keywords

Absorption; Biological Availability; Child; Half-Life; Humans; Pharmaceutical Preparations; Pharmacokinetics; Tissue Distribution

Recommended Citation

Wagner, J. B., Abdel-Rahman, S. M. Pediatric pharmacokinetics. Pediatrics in review / American Academy of Pediatrics 34, 258-269 (2013).