PMCID: PMC6306856 DOI: 10.3390/ht7040039
Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Pediatric tumors have a different genetic make-up, with a fewer number of actionable targets than adult tumors. Nevertheless, precision oncology in the pediatric population has greatly improved the survival of patients with leukemia and solid tumors. This review discusses the current status of pediatric precision oncology and the different clinical scenarios in which it can be effectively applied.
Precision Medicine; High-Throughput Nucleotide Sequencing; Neoplasms; Pediatrics; Mutation
actionable mutations; next generation sequencing; pediatric cancer; precision medicine
Children's Research Institute
Ahmed, Atif; Vundamati, Divya S.; Farooqi, Midhat S.; and Guest, Erin M., "Precision Medicine in Pediatric Cancer: Current Applications and Future Prospects." (2018). Manuscripts, Articles, Book Chapters and Other Papers. 1317.