Document Type

Article

Publication Date

12-13-2018

Identifier

PMCID: PMC6306856 DOI: 10.3390/ht7040039

Abstract

Precision oncologic medicine is an emerging approach for cancer treatment that has recently taken giant steps in solid clinical practice. Recent advances in molecular diagnostics that can analyze the individual tumor's variability in genes have provided greater understanding and additional strategies to treat cancers. Although tumors can be tested by several molecular methods, the use of next-generation sequencing (NGS) has greatly facilitated our understanding of pediatric cancer and identified additional therapeutic opportunities. Pediatric tumors have a different genetic make-up, with a fewer number of actionable targets than adult tumors. Nevertheless, precision oncology in the pediatric population has greatly improved the survival of patients with leukemia and solid tumors. This review discusses the current status of pediatric precision oncology and the different clinical scenarios in which it can be effectively applied.

Journal Title

High Throughput

Volume

7

Issue

4

MeSH Keywords

Precision Medicine; High-Throughput Nucleotide Sequencing; Neoplasms; Pediatrics; Mutation

Keywords

actionable mutations; next generation sequencing; pediatric cancer; precision medicine

Collection

Children's Research Institute

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