CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements.
Document Type
Article
Publication Date
1-1-2019
Identifier
PMCID: PMC6479273; DOI: 10.2217/pgs-2018-0143
Abstract
Warfarin continues to be the mainstay therapy for preventing thrombus formation. Although pharmacogenetic algorithms have shown higher predictability of the optimal warfarin dose and lower occurrence of bleeding episodes, they often do not include ethno-specific genetic variants relevant to non-Europeans. This case report describes a rare missense variant at exon 9 of CYP2C9 (rs202201137; c.1370A>G transition; p.Asn457Ser) found in a Puerto Rican patient with low warfarin dose requirements (3 mg/day). The haplotype characterized by two amino acid changes, Asn457Ser and Arg144Cys (rs1799853; c.430C>T), has been designated CYP2C9*61 by the Pharmacogene Variation Consortium. According to prediction scores assessed with the Combined Annotation Dependent Depletion tool, CYP2C9*61 (p.Asn457Ser) was classified as nondeleterious, therefore its impact on CYP2C9 enzymatic activity cannot be postulated.
Journal Title
Pharmacogenomics
Volume
20
Issue
1
First Page
3
Last Page
8
MeSH Keywords
Warfarin/administration and dosage; Hispanic Americans; Haplotypes; High-Throughput Nucleotide Sequencing; Pharmacogenetics
Keywords
Hispanics; anticoagulation; haplotype; next-generation sequencing; pharmacogenetics (PGx); warfarin
Recommended Citation
Claudio-Campos KI, González-Santiago P, Renta JY, et al. CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements. Pharmacogenomics. 2019;20(1):3-8. doi:10.2217/pgs-2018-0143
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Comments
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