Document Type
Article
Publication Date
11-12-2018
Identifier
PMCID: PMC6233265 DOI: 10.1186/s13063-018-2984-x
Abstract
BACKGROUND: Most smokers struggle to overcome tobacco addiction. Neuroscientific models of addiction emphasize the importance of brain regions associated with cognitive control and reward to understand the cycle of addiction and relapse. During an attempt at abstinence, the cognitive control system appears to be underpowered to override the heightened reward system of the addicted brain. Thus, one neural target for treatment is to strengthen the cognitive control system. It may be possible to improve the functioning of the cognitive control system via deliberate practice.
METHODS/DESIGN: This study will determine the effects of practicing delaying smoking on brain and behavioral measures of cognitive control. Smoking patterns will be monitored for 1 week and then smokers (N = 80) will be randomized to either practice cognitive control by delaying their first cigarette of the day for 2 weeks (practice group) or they will continue monitoring only (no practice group). Functional magnetic resonance imaging will be performed while smokers regulate their responses to smoking images (i) at baseline and (ii) after 2 weeks of practice (or no practice).
DISCUSSION: The primary aim of this study will be to identify the impact of practicing cognitive control on functional brain activation changes in response to smoking cues. If successful, this project will establish a neurobiological biomarker for increasing cognitive control and demonstrate the feasibility of neuroimaging methods to predict the efficacy of an intervention without a large clinical trial.
TRIAL REGISTRATION: ClinicalTrials.gov, NCT03080844 . Registered March 15, 2017.
Journal Title
Trials
Volume
19
Issue
1
First Page
623
Last Page
623
MeSH Keywords
Adolescent; Adult; Brain; Cognition; Electronic Data Processing; Humans; Magnetic Resonance Imaging; Middle Aged; Randomized Controlled Trials as Topic; Research Design; Sample Size; Smokers; Smoking; Smoking Cessation; Young Adult
Keywords
Functional magnetic resonance imaging; Randomized trial; Smoking; Study protocol
Recommended Citation
Fox AT, Catley D, Richter KP, et al. Functional brain activation changes associated with practice in delaying smoking among moderate to heavy smokers: study protocol and rationale of a randomized trial (COPE). Trials. 2018;19(1):623. Published 2018 Nov 12. doi:10.1186/s13063-018-2984-x
Included in
Behavioral Medicine Commons, Nervous System Commons, Radiology Commons, Substance Abuse and Addiction Commons
Comments
Secondary source ID
Grant support
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Publisher's Link: https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2984-x