Individualizing the use of medications in children: making Goldilocks happy.

Creator(s)

James S. Leeder, Children's Mercy HospitalFollow
J T. Brown, Children's Mercy Hospital
Sarah E. Soden, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

9-2014

Identifier

DOI: 10.1038/clpt.2014.130

Abstract

To date, implementation of precision medicine for children has been limited. Extrapolation of adult experience streamlines pediatric drug development programs, and physiologically based pharmacokinetic models aid pediatric dose selection on a population basis. To achieve clinically viable individualization of drug therapy, genotype-stratified pharmacokinetic studies can efficiently characterize the extremes of the dose-exposure relationship. Reducing variability in exposure through genotype-based dosing may improve identification of genetic factors contributing to response, ultimately improving drug therapy for children.

Journal Title

Clinical pharmacology and therapeutics

Volume

96

Issue

3

First Page

304

Last Page

306

MeSH Keywords

Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Dosage Calculations; Genotype; Humans; Infant; Infant, Newborn; Patient Safety; Pharmaceutical Preparations; Pharmacogenetics; Pharmacokinetics; Phenotype; Risk Assessment; Risk Factors

Keywords

Age Factors; Dose-Response Relationship, Drug; Drug Dosage Calculations; Genotype; Patient Safety; Pharmaceutical Preparations; Pharmacogenetics; Pharmacokinetics; Phenotype; Risk Assessment; Risk Factors

Comments

Grant support

• 1 R01 HD058556/HD/NICHD NIH HHS/United States
• 1 T32 HD069038/HD/NICHD NIH HHS/United States

Recommended Citation

Leeder, J. S., Brown, J. T., Soden, S. E. Individualizing the use of medications in children: making Goldilocks happy. Clinical pharmacology and therapeutics 96, 304-306 (2014).