Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary dysplasia.
Document Type
Article
Publication Date
3-2014
Identifier
DOI: 10.1038/jp.2013.152; PMCID: PMC7099681
Abstract
OBJECTIVE: Assess the impact of intercurrent respiratory infections in infants(GA).
STUDY DESIGN: A retrospective cohort study of 111 infants bornGA, controlling for bronchopulmonary dysplasia (BPD) severity and assessing pulmonary health over the first year of life through oxygen, diuretic and inhaled steroid use.
RESULT: Regression analysis showed viral infections increased oxygen use (odds ratio (OR) of 15.5 (confidence interval (CI)=3.4, 71.3)). The trend test showed increasing numbers of viral infections were associated with increased oxygen (OR (95% CI)=6.4 (2.3 to 17.4), P=0.0003), diuretic (OR (95% CI)=2.4 (1.1to 5.2), P=0.02) and inhaled steroid use (OR (95% CI)=2.2 (1.003 to 5.2), P=0.049), whereas bacterial infections were not.
CONCLUSION: Viral infections caused more long-term pulmonary morbidity/mortality than bacterial infections on premature lung health, even when controlling for BPD.
Journal Title
Journal of perinatology : official journal of the California Perinatal Association
Volume
34
Issue
3
First Page
223
Last Page
228
MeSH Keywords
Administration, Inhalation; Bacterial Infections; Bronchopulmonary Dysplasia; Diuretics; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Logistic Models; Lung Diseases; Male; Oxygen Inhalation Therapy; Respiratory Tract Infections; Retrospective Studies; Steroids; Virus Diseases
Keywords
Administration, Inhalation; Bacterial Infections; Bronchopulmonary Dysplasia; Diuretics; Female; Follow-Up Studies; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Logistic Models; Lung Diseases; Male; Oxygen Inhalation Therapy; Respiratory Tract Infections; Retrospective Studies; Steroids; Virus Diseases
Recommended Citation
Taylor, J. B., Nyp, M. F., Norberg, M., Dai, H., Escobar, H., Ellerbeck, E., Truog, W. E. Impact of intercurrent respiratory infections on lung health in infants born <29 weeks with bronchopulmonary>dysplasia. Journal of perinatology : official journal of the California Perinatal Association 34, 223-228 (2014).
