Document Type

Article

Publication Date

6-2021

Identifier

DOI: 10.1177/0145561319863371

Abstract

The diagnosis of desmoid fibromatosis or other spindle cell tumors in the sinonasal region is very rare in children and needs to be thoroughly confirmed with immunohistochemical and/or molecular tests. We report 2 patients with such rare tumors and describe the use of next-generation sequencing in their evaluation. A 3-year-old female had a 4.4-cm midline nasal cavity mass involving the bony septum and extending into the base of the skull bilaterally. The moderate cellular fibroblastic proliferation revealed areas of thick keloid-like collagen bands and other areas with myxoid edematous stroma. Deep targeted sequencing identified a novel G34V mutation in the

Journal Title

Ear, nose, & throat journal

Volume

100

Issue

5

First Page

NP263

Last Page

NP268

Keywords

fibromatosis; immunohistochemistry; next-generation sequencing; sinonasal; spindle cell

Comments

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

Publisher's Link: https://doi.org/10.1177%2F0145561319863371

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