Document Type
Article
Publication Date
10-22-2018
Identifier
DOI: 10.1186/s13104-018-3857-9; PMCID: PMC6198531
Abstract
OBJECTIVE: Data on early miscarriage incidence is limited due to various social and methodological barriers. We report on 24-month pregnancy outcomes of 299 female Ugandan HIV clients in committed relationships with an intention to conceive. Miscarriage data are reported as auxiliary findings to a larger study (5R01HD072633).
RESULTS: 127 (42%) participants reported a pregnancy during the study; among the remaining 172, 82 indicated they stopped trying to conceive, and 16 dropped out prior to month 24. Of the 127 pregnancies, 55 (43%) resulted in live births, 67 (53%) in spontaneous miscarriage, 1 (< 1%) in stillbirth, 1 (< 1%) in abortion, and 3 (2%) in unknown outcomes. Three-quarters (75%) of miscarriages for which time until miscarriage was available were reported to occur in the first trimester (mean = 11.3 weeks gestation). The 67 participants who reported a miscarriage tended to be older (mean 33 vs. 30 years), but the significance of age did not persist after adjusting for multiple tests. We observed relatively low rates of pregnancy and high rates of miscarriage among this cohort of HIV-positive women wanting to conceive. Rigorously designed studies are needed to better understand the observed high rate of early miscarriage among HIV-infected women.
Journal Title
BMC Res Notes
Volume
11
Issue
1
First Page
753
Last Page
753
MeSH Keywords
Abortion, Spontaneous; Adolescent; Adult; Female; HIV Infections; Humans; Live Birth; Middle Aged; Pregnancy; Pregnancy Rate; Stillbirth; Uganda; Young Adult
Keywords
Early miscarriage; HIV; Miscarriage; Pregnancy outcomes; Serodiscordant; Uganda
Recommended Citation
Finocchario-Kessler S, Goggin K, Staggs V, et al. High report of miscarriage among women living with HIV who want to conceive in Uganda. BMC Res Notes. 2018;11(1):753. Published 2018 Oct 22. doi:10.1186/s13104-018-3857-9
Comments
Grant support
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Publisher's Link: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3857-9