Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit.
Document Type
Article
Publication Date
12-2019
Identifier
DOI: 10.1016/j.clp.2019.08.004
Abstract
In this review of analgesic and sedation medication in neonates, important classes of old and newer medications commonly used in the neonatal intensive care unit setting are discussed. In addition to drug metabolism, efficacy, and safety for individual drugs, new insights into multimodal analgesic approaches suggest ways in which multiple analgesic drug classes can be combined to maximize efficacy and minimize toxicity. Opiate pharmacogenetics and the potential for a precision therapeutics approach is explored, with a final description of gaps in knowledge and a call for future research of pain and sedation control in the neonatal population.
Journal Title
Clinics in perinatology
Volume
46
Issue
4
First Page
673
Last Page
692
Keywords
Analgesia; Neonatal; Pain; Pharmacology; Sedation
Recommended Citation
Donato J, Rao K, Lewis T. Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit. Clin Perinatol. 2019;46(4):673-692. doi:10.1016/j.clp.2019.08.004
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