Viral etiology of acute gastroenteritis in <2-Year-Old US children in the post-rotavirus vaccine era

Document Type

Article

Publication Date

3-20-2019

Identifier

DOI: 10.1093/jpids/piy077

Abstract

© 2018 The Author(s). Background: The rotavirus disease burden has declined substantially since rotavirus vaccine was introduced in the United States in 2006. The aim of this study was to determine the viral etiology of acute gastroenteritis (AGE) in US children aged (NVSN) of geographically diverse US sites conducts active pediatric population-based surveillance in hospitals and emergency departments. Stool samples were collected from children aged (n = 330) and age-matched healthy controls (HCs) (n = 272) between January and December 2012. Samples were tested by real-time reverse-transcriptase polymerase chain reaction assays {adenovirus (type 40 and 41), norovirus, parechovirus A, enterovirus, sapovirus, and astrovirus} and an enzyme immunoassay (rotavirus). All samples that tested positive were genotyped. Results: Detection rates of pathogens in children with AGE versus those of HCs were, respectively, 23.0% versus 6.6% for norovirus (P 1 virus was more common in children with AGE (16.0%) than in HCs (10.0%) (P =. 03). Conclusions: Norovirus, astrovirus, sapovirus, and rotavirus were detected significantly more in children with AGE than in HCs, and norovirus was the leading AGE-causing pathogen in US children aged 2012.

Journal Title

Journal of the Pediatric Infectious Diseases Society

Volume

8

Issue

5

First Page

414

Last Page

421

Keywords

acute gastroenteritis, children, codetection, epidemiology, genotyping, real-time PCR

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