Enterovirus D68–associated acute respiratory illness — new vaccine surveillance network, United States, July–October, 2017 and 2018

Creator(s)

• Stephanie A. Kujawski, Centers for Disease Control and Prevention
• Claire M. Midgley, National Center for Immunization and Respiratory Diseases
• Brian Rha, National Center for Immunization and Respiratory Diseases
• Joana Y. Lively, National Center for Immunization and Respiratory Diseases
• W. Allan Nix, National Center for Immunization and Respiratory Diseases
• Aaron T. Curns, National Center for Immunization and Respiratory Diseases
• Daniel C. Payne, National Center for Immunization and Respiratory Diseases
• Janet A. Englund, Seattle Children's Hospital
• Julie A. Boom, Texas Children's Hospital Houston
• John V. Williams, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh
• Geoffrey A. Weinberg, University of Rochester School of Medicine and Dentistry
• Mary A. Staat, University of Cincinnati College of Medicine
• Rangaraj Selvarangan, Children's Mercy HospitalFollow
• Natasha B. Halasa, Vanderbilt University Medical Center
• Eileen J. Klein, Seattle Children's Hospital
• Leila C. Sahni, Texas Children's Hospital Houston
• Marian G. Michaels, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh
• Lynne Shelley, University of Rochester School of Medicine and Dentistry
• Monica McNeal, University of Cincinnati College of Medicine
• Christopher J. Harrison, Children's Mercy HospitalFollow
• Laura S. Stewart, Vanderbilt University Medical Center
• Adriana S. Lopez, National Center for Immunization and Respiratory Diseases
• Janell A. Routh, National Center for Immunization and Respiratory Diseases
• Manisha Patel, National Center for Immunization and Respiratory Diseases
• M. Steven Oberste, National Center for Immunization and Respiratory Diseases
• John T. Watson, National Center for Immunization and Respiratory Diseases
• Susan I. Gerber, National Center for Immunization and Respiratory Diseases

Document Type

Article

Publication Date

3-29-2019

Identifier

DOI: 10.15585/mmwr.mm6812a1; PMCID: PMC6448985

Abstract

In the fall of 2014, an outbreak of enterovirus D68 (EV-D68)-associated acute respiratory illness (ARI) occurred in the United States (1,2); before 2014, EV-D68 was rarely reported to CDC (2,3). In the United States, reported EV-D68 detections typically peak during late summer and early fall (3). EV-D68 epidemiology is not fully understood because testing in clinical settings seldom has been available and detections are not notifiable to CDC. To better understand EV-D68 epidemiology, CDC recently established active, prospective EV-D68 surveillance among pediatric patients at seven U.S. medical centers through the New Vaccine Surveillance Network (NVSN) (4). This report details a preliminary characterization of EV-D68 testing and detections among emergency department (ED) and hospitalized patients with ARI at all NVSN sites during July 1-October 31, 2017, and the same period in 2018. Among patients with ARI who were tested, EV-D68 was detected in two patients (0.8%) in 2017 and 358 (13.9%) in 2018. Continued active, prospective surveillance of EV-D68-associated ARI is needed to better understand EV-D68 epidemiology in the United States.

Journal Title

Morbidity and Mortality Weekly Report

Volume

68

Issue

12

First Page

277

Last Page

280

Comments

Grant support

• U01 IP001049/IP/NCIRD CDC HHS/United States
• U01 IP001054/IP/NCIRD CDC HHS/United States
• U01 IP001063/IP/NCIRD CDC HHS/United States

Erratum in

• Erratum: Vol. 68, No. 12. MMWR Morb Mortal Wkly Rep. 2019 Apr 19;68(15):360. doi: 10.15585/mmwr.mm6815a6.PMID: 30998667

Recommended Citation

Kujawski SA, Midgley CM, Rha B, et al. Enterovirus D68-Associated Acute Respiratory Illness - New Vaccine Surveillance Network, United States, July-October, 2017 and 2018 [published correction appears in MMWR Morb Mortal Wkly Rep. 2019 Apr 19;68(15):360]. MMWR Morb Mortal Wkly Rep. 2019;68(12):277-280. Published 2019 Mar 29. doi:10.15585/mmwr.mm6812a1