Rotavirus strain trends during the postlicensure vaccine era: United States, 2008-2013
Document Type
Article
Publication Date
9-1-2016
Identifier
DOI: 10.1093/infdis/jiw233; PMCID: PMC5075963
Abstract
© The Author 2016.
Background. Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.
Methods. Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.
Results. In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.
Conclusions. Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.
Journal Title
Journal of Infectious Diseases
Volume
214
Issue
5
First Page
732
Last Page
738
Keywords
Genotype, Prevalence, Rotavirus, Surveillance, Vaccine
Recommended Citation
Bowen MD, Mijatovic-Rustempasic S, Esona MD, et al. Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013. J Infect Dis. 2016;214(5):732-738. doi:10.1093/infdis/jiw233
COinS
Comments
Grant support