Rotavirus strain trends during the postlicensure vaccine era: United States, 2008-2013

Creator(s)

• Michael D. Bowen, Centers for Disease Control and Prevention
• Slavica Mijatovic-Rustempasic, Centers for Disease Control and Prevention
• Mathew D. Esona, Centers for Disease Control and Prevention
• Elizabeth N. Teel, Centers for Disease Control and Prevention
• Rashi Gautam, Centers for Disease Control and Prevention
• Michele Sturgeon, Centers for Disease Control and Prevention
• Parvin H. Azimi, UCSF Benioff Children's Hospital Oakland
• Carol J. Baker, Texas Children's Hospital
• David I. Bernstein, Cincinnati Children's Hospital Medical Center
• Julie A. Boom, Texas Children's Hospital
• James Chappell, Vanderbilt University Medical Center
• Stephanie Donauer, Cincinnati Children's Hospital Medical Center
• Kathryn M. Edwards, Vanderbilt University Medical Center
• Janet A. Englund, Seattle Children's Hospital
• Natasha B. Halasa, Vanderbilt University Medical Center
• Christopher J. Harrison, Children's Mercy HospitalFollow
• Samantha H. Johnston, UCSF Benioff Children's Hospital Oakland
• Eileen J. Klein, Seattle Children's Hospital
• Monica M. McNeal, Cincinnati Children's Hospital Medical Center
• Mary Moffatt, Children's Mercy HospitalFollow
• Marcia A. Rench, Texas Children's Hospital
• Leila C. Sahni, Texas Children's Hospital
• Rangaraj Selvarangan, Children's Mercy HospitalFollow
• Mary A. Staat, Cincinnati Children's Hospital Medical Center
• Peter G. Szilagyi, University of California, Los Angeles
• Geoffrey A. Weinberg, University of Rochester School of Medicine and Dentistry
• Mary E. Wikswo, Centers for Disease Control and Prevention
• Umesh D. Parashar, Centers for Disease Control and Prevention
• Daniel C. Payne, Centers for Disease Control and Prevention

Document Type

Article

Publication Date

9-1-2016

Identifier

DOI: 10.1093/infdis/jiw233; PMCID: PMC5075963

Abstract

© The Author 2016.

Background. Group A rotaviruses (RVA) are a significant cause of pediatric gastroenteritis worldwide. The New Vaccine Surveillance Network (NVSN) has conducted active surveillance for RVA at pediatric hospitals and emergency departments at 3-7 geographically diverse sites in the United States since 2006.

Methods. Over 6 consecutive years, from 2008 to 2013, 1523 samples from NVSN sites that were tested positive by a Rotaclone enzyme immunoassay were submitted to the Centers for Disease Control and Prevention for genotyping.

Results. In the 2009, 2010, and 2011 seasons, genotype G3P[8] was the predominant genotype throughout the network, with a 46%-84% prevalence. In the 2012 season, G12P[8] replaced G3P[8] as the most common genotype, with a 70% prevalence, and this trend persisted in 2013 (68.0% prevalence). Vaccine (RotaTeq; Rotarix) strains were detected in 0.6%-3.4% of genotyped samples each season. Uncommon and unusual strains (eg, G8P[4], G3P[24], G2P[8], G3P[4], G3P[6], G24P[14], G4P[6], and G9P[4]) were detected sporadically over the study period. Year, study site, and race were found to be significant predictors of genotype.

Conclusions. Continued active surveillance is needed to monitor RVA genotypes in the United States and to detect potential changes since vaccine licensure.

Journal Title

Journal of Infectious Diseases

Volume

214

Issue

5

First Page

732

Last Page

738

PubMed ID

27302190

Keywords

Genotype, Prevalence, Rotavirus, Surveillance, Vaccine

Comments

Grant support

• CC999999/ImCDC/Intramural CDC HHS/United States
• U01 IP000461/IP/NCIRD CDC HHS/United States

Recommended Citation

Bowen MD, Mijatovic-Rustempasic S, Esona MD, et al. Rotavirus Strain Trends During the Postlicensure Vaccine Era: United States, 2008-2013. J Infect Dis. 2016;214(5):732-738. doi:10.1093/infdis/jiw233