No evidence of vancomycin minimal inhibitory concentration creep or heteroresistance identified in pediatric staphylococcus aureus blood isolates

Creator(s)

Jennifer Goldman, Children's Mercy Kansas CityFollow
Christopher J. Harrison, Children's Mercy HospitalFollow
Angela MyersFollow
Mary Anne Jackson, Children's Mercy HospitalFollow
Rangaraj Selvarangan, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

1-1-2014

Identifier

DOI: 10.1097/01.inf.0000436281.18687.0c; PMCID: PMC4608429

Abstract

We evaluated vancomycin minimum inhibitory concentration (MIC) trends by 3 methods (broth microdilution, Etest and Vitek 2) in 208 Staphylococcus aureus blood isolates from 2006 to 2009 and assessed for heteroresistance. Vancomycin MICs did not increase nor was heteroresistance identified. Etest yielded higher MIC results than the other 2 methods. No MIC was >2 μg/mL by any testing method. Copyright © 2013 by Lippincott Williams & Wilkins.

Journal Title

Pediatric Infectious Disease Journal

Volume

33

Issue

2

First Page

216

Last Page

218

Keywords

heteroresistance, resistance, Staphylococcus aureus, vancomycin

Comments

Grant support

• T32 HD069038/HD/NICHD NIH HHS/United States

Recommended Citation

Goldman, J., Harrison, C. J., Myers, A., Jackson, M., Selvarangan, R. No evidence of vancomycin minimal inhibitory concentration creep or heteroresistance identified in pediatric staphylococcus aureus blood isolates Pediatric Infectious Disease Journal 33, 216-218 (2014).